Published in Health Business Week, April 23rd, 2004
"CBP can function as a tumor suppressor, but the mechanisms that govern oncogenesis in its absence are unknown. Here we show that CBP inactivation in mouse thymocytes leads to lymphoma", reported scientists from the Mayo Clinic.
"Although CBP has been implicated in the transactivation functions of p53, development of these tumors does not seem to involve loss of p53 activity. CBP-null tumors show reduced levels of P27(Kip1) and increased levels of cyclin E andSkp2, two oncoproteins that can promote p27(Kip1) proteolysis. Reduction of p27(Kip1) by introduction of a...
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