National Yang Ming University
Hepatitis C virus core protein has three means of modulating p53 activity
Published in Health Business Week, June 11th, 2004
"Oncogenic virus proteins often target tumor suppressor p53 during virus life cycle. In the case of hepatitis C virus (HCV) core protein, it has been shown to affect p53-dependent transcription. Here, we further characterized the in vitro and in vivo interactions between HCV core protein and p53 and showed that these two proteins colocalized in subnuclear granular structures and the perinuclear area," investigators in Taiwan report.
"By use of a reporter assay, we observed that while low level of HCV core protein enhanced the transactivational activity of p53, high level of...
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Source: Health Business Week (2004-06-11)
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