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Washington University

Major factors of lipid storage and utilization in adipocytes examined

Published in Health Business Week, July 9th, 2004

Sequential ordered fatty acid alpha oxidation and Delta 9 desaturation are major determinants of lipid storage and utilization in differentiating adipocytes.

According to recent research from the United States, "Herein, we exploit the power of global lipidomics to identify the critical role of peroxisomal processing of fatty acids in adipocyte lipid storage and metabolism. Remarkably, 3T3-L1 differentiating adipocytes rapidly acquired the ability to alpha oxidize unbranched fatty acids, which is manifested in the accumulation of odd chain length unbranched fatty acids in all major lipid classes. Moreover, in differentiating adipocytes, unsaturated odd chain length fatty...

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