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Baylor College of Medicine

P19(ARF) sustains normal cell proliferation rate during pregnancy

Published in Health Business Week, July 9th, 2004

P19(ARF) functions primarily to sustain normal cell proliferation in mammary gland development during pregnancy, researchers report.

"This study demonstrated, for the first time, the following events related to p19(ARF) involvement in mammary gland development: 1) Progesterone appears to regulate p19(ARF) in normal mammary gland during pregnancy. 2) p19(ARF) expression levels increased six-fold during pregnancy, and the protein level plateaus during lactation. 3) During involution, p19(ARF) protein level remained at high levels at 2 and 8 days of involution and then, declined sharply at day 15," Y.J. Yi and colleagues reported.

"Absence of p19(ARF)...

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