Yale University

Role of gap junctions in liver elucidated

Published in Health Business Week, November 12th, 2004

The role of hepatic gap junctions has been elucidated.

"Gap junctions are thought to be necessary for proper tissue function. However, no clear hepatic phenotype has been described in patients lacking connexin 32 (Cx32), the principal gap junction in liver," researchers in the United States explained.

"To determine the physiological role of Cx32 in liver," P.R.A.V. Correa and colleagues at Yale University "compared the response of wild type and Cx32-deficient mice to endotoxin, since this stress increases serum levels of hormones that bind to receptors that are asymmetrically distributed across the hepatic lobule."

"In hepatocyte...

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Source: Health Business Week (2004-11-12)

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