Published in Health Business Week, January 14th, 2005
"Human immunodeficiency virus type 1 (HIV-1) cDNA synthesis is inhibited in cells from some nonhuman primates by an activity called Lv1. Sensitivity to restriction by Lv1 maps to a region of the HIV-1 CA required for interaction with the cellular protein cyclophilin A.
"A similar antiviral activity in mammalian cells, Ref1, inhibits reverse transcription of marine leukemia virus (MLV), but only with viral strains bearing N-tropic CA," scientists in the United States report.
"Disruption of the HIV-1 CA-cyclophilin A interaction inhibits Lv1 restriction in...
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