Jikei University, Tokyo

Patients in Japan with liver cancer harbor cytochrome P450 polymorphisms

Published in Health Business Week, September 30th, 2005

Patients in Japan with liver cancer harbor cytochrome P450 polymorphisms.

"The carcinogenic process can be modulated by exposure to endogenous or environmental substance(s) acting as carcinogens or protocarcinogens. Polymorphic enzymes of cytochrome P450 (CYP) that play a role in detoxication/toxication of such substances via metabolization may account for the interpatient variability of clinical course in cancers such as hepatocellular carcinoma (HCC)," investigators in Japan report.

"Many CYP genetic polymorphisms, which may change enzyme activity, are known to exist in Japanese. The aim of the present study was to compare the frequencies of CYP...

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Source: Health Business Week (2005-09-30)

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