University A. Avogadro, Novara
Platelet activation analyzed, role of hepatocyte growth factor revealed
Published in Health Business Week, October 21st, 2005
"Circulating HGF is significantly increased in a number of thrombus-associated disorders. Since platelets play a pivotal role in thrombogenesis, the ability of HGF to interact with human platelets was investigated," wrote D. Pietrapiana and colleagues, University A. Avogadro.
"This paper shows for the first time that human platelets express HGF receptor, the Tyr kinase encoded by c-MET gene. At physiological concentrations HGF was found to inhibit both glycoprotein alphaIIb beta3 activation and...
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Source: Health Business Week (2005-10-21)
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