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University Claude Bernard Lyon 1

Indices of bone formation increase with teriparatide

Published in Health Business Week, November 18th, 2005

Although different mechanistically from alendronate, indices of bone formation increase with teriparatide.

"An 18-month randomized double-blind study in postmenopausal women with osteoporosis was conducted" by scientists in France "to compare the effects of once-daily teriparatide 20 mcg with alendronate 10 mg on bone histomorphometry. Biopsies were obtained from 42 patients. Indices of bone formation were significantly higher after 6 to 18 months of teriparatide compared with alendronate treatment. Alendronate and teriparatide increased BMD, assessed by DXA, by different mechanisms of action, supported by changes in biochemical markers of bone turnover."

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