University of Florence

Neuronal nitric oxide synthase varies in systemic sclerosis skin

Published in Health Business Week, March 10th, 2006

According to recent research from Italy published in the journal Arthritis and Rheumatism, neuronal nitric oxide synthase varies in systemic sclerosis (SSc) skin.

"In SSc, derangement of the peripheral nervous system is linked to vascular tone dysfunction. Nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS, NOS-I) might play a dynamic role in the control of vascular tone."

"This study was performed to verify, by immunohistochemical and biochemical analyses, the presence and expression of nNOS and protein gene product 9.5 (PGP 9.5) in SSc skin, in different subsets and various phases of the disease," wrote L. Ibbamanneschi and...

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Source: Health Business Week (2006-03-10)

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