Nanjing Medical University

Immunotherapeutic potential of adenoviral-mediated gene transfer revealed

Published in Health Business Week, June 30th, 2006

In a recently published study, investigators in the People's Republic of China reported on the effects of adenoviral gene transfer of mutated I kappa B alpha, a novel inhibitor of NF-kappa B, on human monocyte-derived dendritic cells.

L.F. Zhou and colleagues, Nanjing Medical University, wrote that the study was done "to investigate the effects of adenoviral gene transfer of I kappa B alpha mutant (I kappa B alpha M), a novel inhibitor of nuclear factor kappa B (NF-kappa B), on apoptosis, phenotype and function of human monocyte-derived dendritic cells (DC)."

The researchers explained, "Monocytes were cocultured with granulocyte/macrophage...

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Source: Health Business Week (2006-06-30)

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