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Pharmacokinetics

Recent findings in pharmacokinetics described by investigators from Wyeth, Research Department

Published in Health Business Week, September 28th, 2007

Scientists discuss in "Metabolism, excretion, and pharmacokinetics of [14C]tigecycline, a first-in-class glycylcycline antibiotic, after intravenous infusion to healthy male subjects" new findings in pharmacokinetics. "Tigecycline, a novel, first-in-class glycylcycline antibiotic, has been approved for the treatment of complicated intra-abdominal infections and complicated skin and skin structure infections. The pharmacokinetics, metabolism, and excretion of [(14)C]tigecycline were examined in healthy male volunteers," scientists in the United States report.

"Tigecycline has been shown to bind to bone; thus, to minimize the amount of radioactivity binding to bone and to...

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