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New data from RIKEN illuminate research in life sciences

Published in Health Business Week, January 4th, 2008

A report, 'Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice,' is newly published data in Development. "Mammalian metaphase II (mII) exit and embryogenesis are induced at fertilisation by a signal thought to come from the sperm protein, phospholipase C-zeta (PLCZ1). Meiotic progression can also be triggered without sperm, as in parthenogenesis, although the classic mouse in vivo parthenogenetic model, LT/Sv, fails in meiosis I owing to an unknown molecular etiology," scientists in Kobe, Japan report.

"Here, we dissect PLCZ1 specificity and function in vivo and address its ability to interfere with maternal...

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