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Hypertension Animal Studies

Research from Kyowa Hakko Kogyo Co., Ltd. in the area of hypertension animal studies described

Published in Health Business Week, March 21st, 2008

Scientists discuss in 'Benidipine, an anti-hypertensive drug, inhibits reactive oxygen species production in polymorphonuclear leukocytes and oxidative stress in salt-loaded stroke-prone spontaneously hypertensive rats' new findings in hypertension. "Oxidative stress is associated with exacerbation of renal injuries in hypertension. In clinical studies benidipine hydrochloride (benidipine), a dihydropyridine calcium channel blocker with antioxidant activity, reduced oxidative stress," investigators in Shizuoka, Japan report.

"However, the mechanism of suppression of oxidative stress remains to be fully characterized. Reactive oxygen species production by...

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