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Acute Lymphoblastic Leukemia
St. Jude Discovery Offers New Avenues to Understanding an Aggressive Form of Leukemia
May 2nd, 2008
Researchers at St. Jude Children's Research Hospital have discovered evidence that a series of genetic mutations work together to initiate most cases of an aggressive and often-fatal form of acute lymphoblastic leukemia (ALL). These defects, known as "cooperating oncogenic lesions," include the deletion of a gene, IKZF1, whose protein, Ikaros, normally helps guide the development of a blood stem cell into a lymphocyte. The researchers also found that loss of the same gene accompanied the transformation of chronic myelogenous leukemias (CMLs) to a life-threatening acute stage. "These findings provide new avenues to pursue to gain a better...
Source: Health Business Week (2008-05-02)
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