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Enzyme Research
Findings in enzyme research reported from Amgen, Inc., Department of Medicinal Chemistry
May 16th, 2008
Scientists discuss in 'Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation' new findings in enzyme research. According to a study from the United States, "The lymphocyte-specific kinase (Lck), a member of the Src family of cytoplasmic tyrosine kinases, is expressed in T cells and natural killer (NK) cells. Genetic evidence, including knockout mice and human mutations, demonstrates that Lck kinase activity is critical for normal T cell development, activation, and signaling." "Selective inhibition of Lck is expected to...
Source: Health Business Week (2008-05-16)
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