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Kidneys
Research on kidneys discussed by scientists at AstraZeneca
May 16th, 2008
Data detailed in 'The role of permeability in drug ADME/PK, interactions and toxicity--presentation of a permeability-based classification system (PCS) for prediction of ADME/PK in humans' have been presented. According to a study from Sweden, "The objective was to establish in vitro passive permeability (Pe) vs in vivo fraction absorbed (fa)-relationships for each passage through the human intestine, liver, renal tubuli and brain, and develop a Pe-based ADME/PK classification system (PCS). Pe-and intestinal fa-data were taken from an available data set." "Hepatic fa was calculated based on extraction ratios of the unbound fraction of drugs (with support from animal in...
Source: Health Business Week (2008-05-16)
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