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Life Sciences
New life sciences study results reported from Wyeth
May 16th, 2008
Data detailed in 'Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)' have been presented. "We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previously we reported that subtle structural changes with this and related templates produced functional switches between agonist and antagonist properties (Fensome et al. Biorg. Med. Chem. Lett. 2002, 12, 3487; 2003, 13,...
Source: Health Business Week (2008-05-16)
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