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Life Sciences
Reports from Amgen, Inc. add new data to research in life sciences
May 16th, 2008
Data detailed in 'Elucidation of signaling and functional activities of an orphan GPCR, GPR81' have been presented. According to recent research from the United States, "GPR81 is an orphan G protein-coupled receptor (GPCR) that has a high degree of homology to the nicotinic acid receptor GPR109A. GPR81 expression is highly enriched and specific in adipocytes." "However, the function and signaling properties of GPR81 are unknown because of the lack of natural or synthetic ligands. Using chimeric G proteins that convert Gi-coupled receptors to Gq-mediated inositol phosphate (IP) accumulation, we show that GPR81 can constitutively increase IP accumulation in HEK293 cells...
Source: Health Business Week (2008-05-16)
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