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Life Sciences
Study results from Pfizer Inc. in the area of life sciences published
May 16th, 2008
New investigation results, 'N-methylation and N-formylation of a secondary amine drug (varenicline) in an osmotic tablet,' are detailed in a study published in Journal of Pharmaceutical Sciences. According to a study from the United States, "Significant degradation of the amine-based smoking cessation drug varenicline tartrate in an early development phase osmotic, controlled-release (CR) formulation yields predominantly two products: N-methylvarenicline (NMV) and N-formylvarenicline (NFV). NMV is produced by reaction of the amine moiety with both formaldehyde and formic acid in an Eschweiler-Clarke reaction, while NFV is formed by reaction of formic acid alone with...
Source: Health Business Week (2008-05-16)
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