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Monoclonal Antibodies
Recent findings in monoclonal antibodies described by researchers from Genentech, Inc.
May 16th, 2008
"Biotechnological companies and regulatory agencies are pursuing the complete characterization of protein therapeutics in every detail as a means to mitigate risks of product quality related safety issues. During the characterization of a recombinant humanized monoclonal antibody (referred to as rhuMAb), electrospray mass spectrometric analysis suggested that the light chain was highly glycated," scientists in the United States report. "The glycated and unglycated materials, separated using boronate affinity chromatography, were fully characterized using tryptic peptide mapping and tandem mass spectrometry. Using an automatic SEQUEST search of the single protein...
Source: Health Business Week (2008-05-16)
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