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Monoclonal Antibodies
Researchers at Merck & Company, Inc. release new data on monoclonal antibodies
May 16th, 2008
Scientists discuss in 'Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies' new findings in monoclonal antibodies. "Temperature-induced unfolding of three humanized IgG1 monoclonal antibodies and their Fab and Fc fragments was monitored by differential scanning calorimetry at neutral pH. With some exceptions, the thermogram of the intact antibody presents two peaks and the transition with the larger experimental enthalpy contains the contribution from the Fab fragments," investigators in the United States report. "Although the measured enthalpy was similar for all three Fab fragments studied, the apparent melting temperatures were...
Source: Health Business Week (2008-05-16)
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