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Enzyme Research

Research reports from Eli Lilly and Company provide new insights into enzyme research

Published in Health Business Week, May 23rd, 2008

Researchers detail in 'AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase,' new data in enzyme research. According to a study from the United States, "AGPAT6 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) family that appears to be important in triglyceride biosynthesis in several tissues, but the precise biochemical function of the enzyme is unknown. In the current study, we show that AGPAT6 is a microsomal glycerol-3-phosphate acyltransferase (GPAT)."

"Membranes from HEK293 cells overexpressing human AGPAT6 had higher levels of GPAT activity. Substrate specificity studies suggested that AGPAT6 was active against both saturated...

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