Menopause

Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate

Published in Health Business Week, September 26th, 2008

Bionovo, Inc. (NASDAQ:BNVI) announced the publishing of a paper in the journal for the American Society for Pharmacology and Experimental Therapeutics, Drug Metabolism and Disposition, entitled "Oxidative In Vitro Metabolism of Liquiritigenin, a Bioactive Compound Isolated from the Chinese Herbal Selective Estrogen Beta-Receptor Agonist MF101."

Liquiritigenin is one of the active compounds of MF101, Bionovo's drug candidate for the treatment of menopausal hot flashes, currently poised to start Phase 3 clinical testing.

The paper describes in vitro metabolism of Liquiritigenin which is almost exclusively metabolized by cytochrome P450 3A4. The...

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Source: Health Business Week (2008-09-26)

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