University of Oxford, U.K.

"Second messenger" NAADP shows fast, dose-related impact on satiety cycle

Published in Health Insurance Law Weekly, May 1st, 2005

One traditional approach to pharmaceutical design uses so-called "first messengers" - hormones, other natural facilitators or synthetic products - to initiate various cellular cascades for the desired physiological effect. To date, despite concerted efforts at all levels of research, this approach has failed to develop a truly successful obesity drug to address this major global health problem.

Enter a recently discovered and already controversial natural molecule called nicotinic acid adenine dinucleotide phosphate (NAADP), which is active in cells from plants to humans. NAADP is thought to be a so-called "second messenger," because it works from inside cells, rather...

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Source: Health Insurance Law Weekly (2005-05-01)

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