Evans Biomedical Research Center
Lithium promotes cell survival in the absence of soluble survival factors
Published in Health Insurance Law Weekly, May 8th, 2005
Scientists writing in the American Journal of Physiology - Renal Physiology report, "Although Wnt signaling antagonizes the effect of proapoptotic triggers, its role in regulating the default pathway of apoptosis is less well defined.
"The present study examines the hypothesis that lithium (Li+) and (2'Z,3'E)-6-bromoindirubin-3'-oxime (BIO), two glycogen synthase kinase-3beta (GSK3beta) inhibitors, promote survival of growth factor-deprived renal epithelial cells by activating the Wnt...
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