University of California, San Francisco

AMPA receptor function analyzed, stargazing-mediated modulation defined

Published in Health Insurance Law Weekly, August 14th, 2005

According to a study from the United States, stargazin modulates alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor gating and trafficking by distinct domains.

"AMPA receptors mediate fast excitatory synaptic transmission in the brain. These ion channels rapidly deactivate and desensitize, which determine the time course of synaptic transmission.

"Here, we find that the AMPA receptor interacting protein, stargazin, not only mediates AMPA receptor trafficking but also shapes synaptic responses by slowing channel deactivation and desensitization," wrote S. Tomita and colleagues, University of California, San Francisco.

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Source: Health Insurance Law Weekly (2005-08-14)

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