Karolinska Institute

Polyomavirus virus-like particles prevent growth of breast tumors

Published in Health Insurance Law Weekly, August 14th, 2005

A single vaccination with polyomavirus VP1/VP2Her2 virus-like particles prevents outgrowth of HER-2/neu-expressing tumors.

According to recent research from Sweden and Italy, "Murine polyomavirus (MPyV) VP1 virus-like particles (VLPs), containing a fusion protein between MPyV VP2 and the extracellular and transmembrane domain of HER-2/neu (Her2), Her2_1-683 PyVLPs, were tested for their ability to vaccinate against Her2-expressing tumors in two different in vivo models. Protection was assessed both against a lethal challenge with a BALB/c mammary carcinoma transfected with human Her2 (D2F2/E2) and against the outgrowth of autochthonous mammary...

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Source: Health Insurance Law Weekly (2005-08-14)

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