Children's Hospital of Philadelphia

Lentiviral vector encoding Gp41-derived fusion inhibitor suppressed HIV

Published in Health Insurance Law Weekly, August 14th, 2005

A self-inactivating lentiviral vector encoding a membrane-expressed Gp41-derived fusion inhibitor suppressed HIV-1 infection.

According to recent research from the United States, "Peptidomimetics of HIV-1 gp41 sequences required for membrane fusion are potent inhibitors of HIV-1 entry. We hypothesize that expression of a membrane-bound gp41-derived fusion inhibitor will confer HIV-1 resistance to primary CD4 T cells. Efficient gene delivery and stable expression of a membrane-bound gp41-derived fusion inhibitor to primary CD4 T cells was accomplished using a self-inactivating lentiviral vector."

"A potent antiviral effect was observed when transduced...

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Source: Health Insurance Law Weekly (2005-08-14)

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