Pennsylvania State University
HBV reverse transcriptase and epsilon RNA sequences are required for interaction
Published in Health Insurance Law Weekly, April 16th, 2006
"Initiation of reverse transcription and nucleocapsid assembly in HBV depends on the specific recognition of an RNA signal (the packaging signal, E) on the pregenomic RNA by the viral reverse transcriptase (RT)," wrote J.M. Hu and colleagues, Pennsylvania State University.
The researchers wrote, "Using an in vitro reconstitution system whereby the cellular heat shock protein 90 chaperone system activates recombinant HBV RT for specific E binding, we have defined the protein and RNA...
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