Umea University, Sweden
Adenovirus types attach to and infect lymphocytes and monocytes
Published in Health Insurance Law Weekly, July 30th, 2006
According to a study from Sweden, "Hematopoietic cells are attractive targets for gene therapy, but the conventional adenovirus (Ad) vectors, based on Ad5, transduce these cells inefficiently. One reason for low permissiveness of hematopoietic cells to infection by species C Ads appears to be inefficient attachment. Vectors pseudotyped with species B fibers are clearly more efficient at transducing hematopoietic cells than Ad5."
"To evaluate which Ad species B types would be the most efficient vectors for...
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