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Health Insurance Law Weekly

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Ben-Gurion University, Israel



Interferon-alpha therapy contributes to weight loss by increasing adipocyte apoptosis



August 13th, 2006

Increased apoptosis of adipocytes contributes to weight loss following interferon-alpha therapy.

"Interferon alpha (IFN-alpha) is produced in response to viral infections and used clinically in the therapy of a variety of cancers and viral infections. IFN-a treatment is often associated with severe weight reduction. To elucidate the mechanism of IFN-associated weight loss, we studied its effect on adipocytes in vitro and in vivo. Diet-induced obese (DIO) C57BL/6 mice were treated continuously for 8 days with human IFN-alpha A/D (100 U/g body weight) or with vehicle alone," researchers in Israel report.

"The body weight and adipose cell size of...


Source: Health Insurance Law Weekly (2006-08-13)

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