British Columbia Cancer Agency

CD38 expressed in myeloblast nuclei during RA-induced differentiation

Published in Health Insurance Week, March 27th, 2005

CD38 is expressed in the nuclei of myeloblastic cells during retinoic acid-induced differentiation.

"The cell surface antigen, CD38, is a 45-kDa transmembrane protein which is predominantly expressed on hematopoietic cells during differentiation," researchers in Canada explained. "As a bifunctional ectoenzyme, it catalyzes the synthesis of cyclic ADP-ribose (cADPR) from NAD⁺ and hydrolysis of either NAD⁺ or cADPR to ADP-ribose."

"All-trans-retinoic acid (RA) is a potent and specific inducer of CD38 in myeloid cells," noted L. Yalcintepe and colleagues at the British Columbia Cancer Agency. In a recent study, they found...

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Source: Health Insurance Week (2005-03-27)

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