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Cooper University Hospital, Camden

Effects of isoflurane on gastrointestinal motility clarified

Published in Health Insurance Week, September 18th, 2005

The effects of isoflurane on gastrointestinal motility have been clarified in a rat model.

"In pre-clinical studies, investigation of oral formulations often necessitates the use of general anesthesia to facilitate deposition of material directly into the stomach," anesthesiologists in New Jersey explained.

"Since the effectiveness of intestinal drug absorption is dependent on gastric emptying (GE) and intestinal motility, drugs that influence either will also influence drug absorption," noted M.C. Torjman and colleagues at Cooper University Hospital in Camden. In a recent study, they "investigated gastrointestinal motility in rats after brief...

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