U.S. National Institute of Allergy & Infectious Diseases

Vaccinia virus entry requires cysteine-rich membrane protein encoded by A16L gene

Published in Health Insurance Week, April 2nd, 2006

The entry of vaccinia virus and cell-cell fusion require a highly conserved cysteine-rich membrane protein encoded by the A16L gene.

According to recent research published in the Journal of Virology, "The vaccinia virus A16L open reading frame encodes a 378-amino-acid protein with a predicted C-terminal transmembrane domain and 20 invariant cysteine residues that is conserved in all sequenced members of the poxvirus family. The A16 protein was expressed late in infection and incorporated into intracellular virus particles with the N-terminal segment of the protein exposed on the surface. The cysteine residues were disulfide bonded via the poxvirus cytoplasmic...

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Source: Health Insurance Week (2006-04-02)

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