Published in Health Insurance Week, October 22nd, 2006
Study 1: A study from Sweden has reported that small interfering RNA (siRNA)-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.
"Type 2 diabetes is associated with defects in insulin signaling and the resulting abnormal glucose and lipid metabolism. The complexity of insulin signaling cascades is highlighted by the existence of multiple isoforms of target proteins implicated in metabolic and gene-regulatory events," wrote K. Bouzakri and colleagues, Karolinska University Hospital.
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