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Health Risk Factor Week

Susan Hasty, Publisher

Table of Contents . . . January 12th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Health Risk Factor Week | Other Publications

AIDS Prevention - U.N. envoy says clerics can help prevent spread of AIDS in Pakistan

Centers for Disease Control & Prevention - Health departments should adopt new notification policies for gay men

Ethicon, Inc. - FDA issues alert on counterfeit polypropylene mesh used in surgery

European Synchrotron Radiation Facility - 3-D synchrotron radiation micro computed tomography reveals bone status

Finance - LanVision reports 14% revenue increase in third quarter compared to last year

Finance - Mariner Health Care agrees to sell $175M of 8.25% senior subordinated notes

Fred Hutchinson Cancer Research Center - B lymphocyte-specific c-Myc expression sparks early events in lymphomagenesis

Hamamatsu University - L-asparaginase treatment may be effective for certain subtypes of AML

Harvard University - HHV-7's U21 transports MHC-I molecules to lysosomes via the ER-lumenal domain

Harvard University - T-cell costimulatory molecules ultimately assign allograft rejection, tolerance

Hiroshima University - p16 Gene transfer causes abnormal nucleation in radiation-treated cancer cells

Hokkaido University -  H. pylori CagA inhibits B cell p53-induced apoptosis; triggers MALT lymphoma

Centers for Disease Control & Prevention - Herpesvirus 8 and Epstein-Barr virus seropositivity among children compared

Hospital Corp. of America - HCA appoints Marilyn Tavenner as group president for outpatient services

Immunicon Corp. - FDA 510(k) clearance granted for the CellTracks Analyzer for HIV/AIDS

Inamed Corp. - FDA dismisses two petitions seeking to delay application review

Ingenium Pharmaceuticals, AG - INGENOtyping agreement inked with Max-Planck Institute

Insmed, Inc. - FDA grants orphan drug designation for rhIGF-I/rhIGFBP-3, SomatoKine

Inst. of Hygiene and Tropical Medicine, Lisbon -  P. jiroveci DHPS mutations not linked to sulfa drugs in Portugese patients

Institute Gustave Roussy - A real-time PCR assay screens for p53 recombinant adenovirus in patient samples

Institute Gustave Roussy - IP hyperthermic chemo techniques must be draconian in order to be effective

Institute J Paoli I Calmettes - LIGHT, along with CD40L, allows activation of DC, IL-12 by memory T helper cells

Instituto Grifols - FDA license granted for intravenous immunoglobulin

Centers for Disease Control & Prevention - Immunohistochemical assay for babesiosis in tissue samples developed

Introgen Therapeutics, Inc. - INGN 241 therapy shows safety and clinical activity in phase I clinical trial

Istituto Superiore di Sanita - HIV Nef induces DC differentiation through Vav signaling

Jagiellonian University - IL-10 release following intracerebral hemorrhage varies depending on hemisphere

Jichi Medical School -  Plasmodium berghei circumsporozoite protein protect against malaria

Johns Hopkins Univ. Hospital - AMACR is essential for optimal growth of prostate cancer cells in vitro

Johns Hopkins University - O-GlcNAc plays role in diabetes, cancer, and neurodegeneration

Karolinska Institute -  Enterococcus enriched with surface protein gene show increased adhesion

Kumamoto University - VLDL/chylomicron plays role in amyloid formation

Kuopio University Hospital - IL-1 receptor antagonist polymorphisms are associated with preeclampsia

M.D. Anderson Cancer Center - IIp45 antagonizes IGFBP-2 stimulation of glioma cell invasion

Centers for Disease Control & Prevention - Increase in rodent-transmitted disease seen in Hawaii

M.D. Anderson Cancer Center - PI3-K pathway may be major pathway for trastuzumab-mediated radiosensitization

M.D. Anderson Cancer Center - p27(KIP1) has a novel role in down-regulation of telomerase activity

Manchester Royal Eye Hospital - HSV keratitis can occur in keratoplasty as host reactivation, donor transmission

Maxygen, Inc. - 5HTIA serotonin receptor agonists suppress P. falciparum growth

Mayo Clinic - A rapid serological assay can identify amyloidogenic transthyretin variants

Mayo Clinic - MAPK pathway may be a potential therapeutic target in ALL

Medical University of Lodz - A whole genome screen reveals five genes associated with multiple sclerosis

Medicare - HHS secretary promotes program's changes at Wisconsin town hall meeting

Medicis - FDA approves dermal filler Restylane

Mentor Corp. - WARF licenses botulinum toxin

Centers for Disease Control & Prevention - Intestinal intussusception associated with adenovirus in Mexican children

Merrimack Pharmaceuticals, Inc. - GTC takes equity position in MM-093 developer

Microbiology & Immunology Inst., Belgrade -  Staphylococcus sciuri group may be an infrequent cause of UTI

NanoBio Corporation - U.S. Department of Defense awards $3.2M contract for antimicrobial nanoemulsions

National Blood Service, Birmingham, UK - HLA-DRB5 allele, DRB5*0112, may be the result of intraexonic recombination

National Cancer Center, Gyeonggi - BRAF mutations do not seem to be involved in gastric cancer development

National Public Health Institute, Turku - BACTEC MGIT 960 effective for TB drug resistance testing

Natl. Inst. of Health & Medical Research, Paris - HIV Nef induces accumulation of MHC II complexes and MVBs

Newcastle General Hospital - DJ-1 gene polymorphism not linked to Parkinson disease

Noninvasive Monitoring Systems, Inc. - AT101 maker announces major narrowing of first quarter loss compared to 2002

Norwegian Univ. of Science & Technology - TOP2A aberration testing may help identify targeted breast cancer therapies

Centers for Disease Control & Prevention - Invalid vaccine doses would cost millions to fix

OraSure Technologies, Inc. - FDA completes inspection of manufacturing facility for oral diagnostics company

Paul Scherrer Institute - HIV TAT basic peptide has low affinity for VEGF receptor 2

Qmed - FDA approves Restylane for soft tissue augmentation

Quality Assurance - HMO report shows need for improved care of children, women in Utah

Radiancy, Inc. - FDA grants clearance for light unit assembly acne vulgaris treatment

Roche - 48-Week data submitted to FDA for full approval of HIV fusion inhibitor

Rowett Research Inst. - CSF treatments, laser light therapy may aid restitution and repair of mucositis

Saegis Pharmaceuticals, Inc. - CNS-focused biopharmaceutical company announces new vice president

Schering, AG - MS-325 for magnetic resonance angiography submitted for approval in the U.S.

Southern Arizona VA Health Care System Hospital - AT1 blockade enhances vasorelaxation during heart failure

Centers for Disease Control & Prevention - Opsonophagocytosis assay effective for Streptococcus pneumoniae antibodies

SpectRx, Inc. - FDA grants second major patent for insulin delivery patch

Staffing - LSU hospital chief to lead Erlanger Health System

Stanford University - VEGF is a prerequisite for exercise-induced hippocampal neurogenesis

Suntory Pharmaceutical Research - HMGene enters obesity drug agreement

Syneron Medical, Ltd. - FDA approves Polaris WR wrinkle treatment system

Telemedicine - A few doctors seeing patients online

Tiax - U.S. patent issued for multilayered dressing

Tohoku University, Japan - II beta-hydroxysteroid dehydrogenase type 2 is expressed in ARDS patient lungs

U.S. Food & Drug Administration - FDA plans to prohibit sales of diet supplements containing ephedra

U.S. Food & Drug Administration - U.S. officials say it's too costly to legalize drug imports

Centers for Disease Control & Prevention - Vaccine shortages affect child immunization programs

U.S. National Institutes of Health - NK cell activating receptor NKp46 is similar to other leukocyte receptors

U.S. Natl. Inst. of Child Health & Human Developme - U.S. NIH alerts parents to winter SIDS risk

Ullevaal University Hospital - HAART has limited effect on hypertension risk

Univ. of Texas Medical Branch - DNA base excision repair proteins help fix oxidative DNA damage

Univ. of Texas SW Medical Center - LDL receptor-related protein controls blood-brain barrier permeability

University of Alberta - TRAIL triggers apoptosis in human malignant glioma cells

University of British Columbia - T-plastin shows potential as Sezary cell-specific marker

University of California-Los Angeles - 12-Lipoxygenase plays role in experimental diabetic nephropathy

University of Edinburgh - TNF-alpha may play an early role in the malignant transformation of liver cells

University of Glasgow -  Trypanosoma homologous recombination changes if mismatch repair is impaired

Centers for Disease Control and Prevention - Cold-adapted influenza A H9N2 reassortant is influenza vaccine candidate

University of Laval - LDL peak particle diameter is highly heritable

University of Maryland - U.S. officials say interviews for HIV study were fabricated

University of Milan - TIPS improves cardiac function in hypovolemic patients

University of Munich - A new B*38 allele, B*3809, was found in a Dutch caucasoid B-cell line

University of New South Wales - DHEA increases macrophage foam-cell formation

University of Paris - 3-D ultrasound assesses lung volume in cases of congenital diaphragmatic hernia

University of Rochester -  Pseudomonas aeruginosa has two quorum sensing systems that could be targeted

University of So. Denmark - PPARdelta transactivation occurs in psoriasis; may be linked to pathology

University of Southern California - "Paper of the year" recognizes significance of gene variance findings

University of Szeged - A whole genome screen reveals 33 genes associated with multiple sclerosis

Chiron Corp. - Experts: Antiquated flu vaccine system needs updating

University of Tokyo - CO poisoning is due to ROS affecting neurons; hypothermia can reduce the damage

University of Tubingen - CD8 T cells expanded on calibrated MHC/anti-CD28-coated microspheres

VA Medical Center, Kansas City - 2-Methoxyestradiol has a biphasic effect on new vessel growth

Vanderbilt University - p63 Amplification, overexpression occurs early in developing lung cancer

W. Australian Ctr. for Pathology & Medical Researc - PCR assay can aid malaria diagnosis in patients with low parasitemia

Washington University -  Cryptococcus neoformans capsule formation can be blocked by RNA interference

West Virginia University - p38 MAPK mediates negative inotropic effect of gp120 on myocytes

World Health Organization - HIV has significant influence on leishmaniasis epidemiology

World Health Organization - U.N.: Spread of polio in West Africa threatens global eradication drive

World Health Organization - WHO: Battle against AIDS will founder without boost to basic healthcare

Al Zytoona University - The prevalence of osteoporosis is high among Jordanian women

Erasmus Medical Center - Drug-coated stents effective in "real world" patients

Wyeth Pharmaceuticals - CDC: Vaccine shortage likely

Family Health International - Nonlatex condoms provide a viable alternative to latex condoms for some men

Gynecological Exams - Patient education, respect key to reducing women's gyn exam anxiety

Hiroshima University -  Helicobacter pylori influences angiogenesis and gastric cancer invasion

Hopital Notre Dame de Bon Secours, Paris - Estrogen counteracts urinary tract infections in postmenopausal women

Influenza - Flu seems to be hitting kids very hard

Inst. of Cancer Prevention, Valhalla - Oral cytology differs between smokers and nonsmokers

Johns Hopkins University - A pair of discoveries helps unravel complex genetics of IBS

Natl. Highway Traffic Safety Admin. - Data show little change in DUI rates

New York State Dept. of Health - Murine models of human liver cancer exemplify malignant mechanisms

Aventis Pasteur - FDA investigating reports of unlicensed influenza vaccine

Oregon Health Sciences University -  Ginkgo biloba prevents memory deficits in Alzheimer disease animal models

Roche - FDA approves labeling for use of Xenical in adolescent patients

RTI International, North Carolina - Inhaled tertiary amyl methyl ether vapor affects reproduction in male rodents

Rutgers State University - Enzyme induction, dietary chemicals may be approaches to cancer chemoprevention

Skinvisible, Inc. - Hand sanitizer provides greater than 99% kill against influenza A in studies

U.S. National Cancer Institute - Occupational cancer among women: Where have we been and where are we going?

U.S. National Cancer Institute - Studies evaluating fenretinide are underway

U.S. National Institutes of Health - NHGRI launches social and behavioral research branch

U.S. Naval Medical Research Ctr. Detachment, Lima - Primaquine effective for prevention of malaria in travelers

United Nations - U.S. labor secretary launches HIV/AIDS initiative in Ghana

Bloomberg School of Public Health - Children get better care with developmental specialists on physician team

Univ. of A Avogadro Piemonte Orientale - Recent insights on the mechanisms of liver preconditioning evaluated

Univ. of Southern California - Tea catechins may reduce breast cancer risk in Asian-American women

University Hospital, Bordeaux - Potential genetic links to diabetes and cardiovascular disease discovered

University Hospital, Orebro - Low incidence of non-Hodgkin lymphoma in Sweden may result from carcinogen bans

University of Barcelona - Chemoembolization improves survival for many with unresectable liver cancer

University of Birmingham - Birt-Hogg-Dube in activation occurs in some renal cell, colorectal cancers

University of Pittsburgh - Miscommunication and poor medical advice contributes to unplanned pregnancies

University of Pittsburgh - Researchers study broccoli-derived chemicals to prevent cancer

University of Witwatersrand - Aflatoxin B-1 and hepatitis B virus synergize to encourage hepatocarcinogenesis

Weight Loss - Hospital's fat-fighting program sets the standard

Cedars-Sinai Medical Center - Specialist suggests pregnant women request vaccine to protect both mom and baby

Women's Capital Corp. - Women are not likely to abuse over-the-counter emergency contraception

510-262-8757 - $15M milestone payment awarded for developments in anticancer compound

Abbott Laboratories - A reversible inhibitor of methionine aminopeptidase-2 quells tumor growth

Able Laboratories, Inc. - FDA grants approval for Indomethacin capsules

Accreditation - Baptist Hospitals in Mississippi earn high JCAHO scores

Advion BioSciences, Inc. - $9M service contract signed for bioanalytical services

Advocate Christ Medical Center - B-type natriuretic peptide also elevated during pulmonary embolism

Allicin International - Garlic compound effective against killer MRSA "superbugs"

Altana AG - Daxas to be submitted for European approval in February 2004

Amgen - Data suggest Aranesp benefits certain cancer patients with anemia

Centers for Disease Control & Prevention - Bat lyssaviruses from Central Asia categorized

Anadys Pharmaceuticals, Inc. - Data reported from phase IB trial of Isatoribine

Aventis - Nautilus Biotech reaches milestone in vaccine collaboration

Axcan Pharma, Inc. - CPMP positive opinion issued in Europe for Photobarr

Barr Laboratories, Inc. - FDA panel votes to allow sale of emergency contraceptive

Bayer Pharmaceuticals Corp. - FDA grants Cipro additional 6 months marketing exclusivity

Beckman Coulter, Inc. - Garrett named president, chief operating officer at biomedical company

Bharathiar University -  Gymnema montanum leaves possess antidiabetic effect

Biomet, Inc. - FDA clears Palacos G antibiotic-loaded bone cement

Biomira, Inc. - Cancer drug development status reported

Biophan Technologies, Inc. - Nanomagnetic particles used as contrast agent improves detail

Centers for Disease Control & Prevention - CDC releases new guidelines for hygiene in dental care settings

Birmingham Heartlands Hospital - A new line probe assay identifies hepatitis B virus precore variants in sera

Breast Cancer - U.S. women's breast cancer diagnosed earlier than European women

Bryan Corporation - FDA grants approval of Sterile Talc Powder

Burnham Institute - TOP2A gene copy number aberration screening important with topoII-inhibitors

Burnham Institute - TR3 induces both proliferation and apoptosis

Burrill & Company - 2003 was biotech's second best year with market cap up 32%

Canadian Blood Services, Toronto - VIP/NTM peptide mimetics show promise for HIV treatment

Cancer Research UK - MSI-low is a real phenomenon that varies in frequency among cancer types

Cancer Research UK - Rare genetic condition sheds light on body's cancer defenses

Catholic University of Leuven - VERSANT HIV drug resistance assay effective

Centers for Disease Control & Prevention - CDC: Flu activity widespread in 45 states

Central Institute of Epidemiology, Moscow - Vaccine reduces meningococcal risk in patients with immune deficiency

Children's Hospital of Philadelphia - Targeting of chemokine receptors may help stop allograft rejection

CHU Vaudois - SLURP-1 is an epidermal neuromodulator; its gene is mutated in Mal de Meleda

Collaborations - EDS signs $320M contract with Blue Cross Blue Shield of Massachusetts

Covalent Group, Inc. - Cardiovascular safety study, other contracts total $8.1M

CryoCor, Inc. - U.S. pivotal trial begins for cardiac cryoblation system

Cutting Edge Information - Launching blockbuster drugs: Marketing budgets push drugs to success

Cutting Edge Information - Market research's role expands, aids pharmaceutical launches

Cytyc Corporation - 20th ThinPrep imaging system shipped to Pennsylvania hospital

Domestic Violence - A third of women in Utah emergency rooms are abuse victims, 40% consider suicide

Centers for Disease Control & Prevention - Cytokines act as mediators for or effectors against rotavirus disease

Dor BioPharma, Inc. - Davenport named VP, business development at drug delivery firm

Duke University -  Rhodotorula fungemia isolates respond best to amphotericin B, posaconazole

Duke University - Cancer survives via signals from nearby blood vessels long before new vessels are grown

Duke University - Having appendix removed by laparoscopy means faster recovery

Duke University - Race affects older Americans' likelihood of getting flu shot

Eclipse Diagnostics, Inc. - Large Scale Biology announces breakthrough diagnostic technology

Eindhoven University of Technology - Mathematical model developed for arterial wall collagen fiber remodeling

Employer-Sponsored Health Insurance - California court bows out of employer-sponsored health insurance ballot fight

Employer-Sponsored Health Insurance - Garment maker's insurance plan leaves workers saddled with bills

Endocare, Inc. - Davenport named CEO at medical device company

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