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British Columbia Cancer Agency
CD38 expressed in myeloblast nuclei during RA-induced differentiation
March 22nd, 2005
CD38 is expressed in the nuclei of myeloblastic cells during retinoic acid-induced differentiation. "The cell surface antigen, CD38, is a 45-kDa transmembrane protein which is predominantly expressed on hematopoietic cells during differentiation," researchers in Canada explained. "As a bifunctional ectoenzyme, it catalyzes the synthesis of cyclic ADP-ribose (cADPR) from NAD+ and hydrolysis of either NAD+ or cADPR to ADP-ribose." "All-trans-retinoic acid (RA) is a potent and specific inducer of CD38 in myeloid cells," noted L. Yalcintepe and colleagues at the British Columbia Cancer Agency. In a recent study, they found...
Source: Health Risk Factor Week (2005-03-22)
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