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Albert Einstein College of Medicine

Research add new data to diabetes pathogenesis body of knowledge

Published in Health Risk Factor Week, March 22nd, 2005

New findings from the United States describe advances in diabetes pathogenesis.

Study 1: Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase.

"Spontaneous autoimmune diabetes development in NOD mice requires both CD8+ and CD4+ T cells. Three pathogenic CD8+ T cell populations (represented by the G9C8, 8.3, and AI4 clones) have been described. Although the antigens for G9C8 and 8.3 are known to be insulin and islet-specific glucose-6-phosphatase catalytic subunit-related protein, respectively, only mimotope peptides had...

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