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Asahikawa Medical College, Hokkaido

Combinatory chemotherapy for metastatic colorectal cancer entered phase II trial

Published in Health Risk Factor Week, July 19th, 2005

Scientists conducted a phase II study of irinotecan, leucovorin, 5-fluorouracil (5FU) and tegafur/uracil (UFT) for metastatic colorectal cancer (MCRC).

"Irinotecan combined with continuous-infusion 5FU has been shown to be an effective and tolerable regimen in the treatment of MCRC. UFT during 5FU infusion enhances plasma 5FU concentration, mimics continuous 5FU infusion and delivers the drug to target tumor cells," researchers in Japan reported.

"We conducted a phase II trial of four-agent combined therapy for MCRC, giving patients (pts) intravenous irinotecan (30 mg/m2 on day 1), leucovorin (LV, 200 mg/m2 on day 1 and 2), 5FU...

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