Birla Institute of Technology & Science, Rajasthan
Abacavir prodrug is found to be more potent than the parent drug against HIV
Published in Health Risk Factor Week, May 16th, 2006
"The synthesis of a new series of abacavir prodrugs involving N2-substitution with various substituted benzaldehyde and ketone derivatives is described," investigators in India report.
"The in vitro anti-HIV activities indicated that compound (3-(2-(4-methylaminobenzylideneamino)-6-(cyclopropylamino)-9H-purin-9-yl)cyclopentyl)methanol (3) was found to be most potent compound with EC50 of 0.05 microM and CC50 of >100 microM with selectivity index of >2000. Compound 3 was found to be...
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