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Respiratory Medicine

Identifying rare genetic disorder early on may minimize damage from certain lung conditions

Published in Health Risk Factor Week, November 14th, 2006

A rare genetic disorder known as alpha-1 antitrypsin (A1AT) deficiency may predispose patients to developing lung conditions, but a new rapid-response test could help identify patients with the deficiency before significant lung damage has occurred.

New research presented at CHEST 2006, the 72nd annual international scientific assembly of the American College of Chest Physicians (ACCP), shows that World Trade Center rescue workers deficient in the A1AT protein who were exposed to environmental irritants had more rapid decline in lung function compared with exposed workers with normal levels of protein. A1AT deficiency alters the ability of the lungs and liver to control...

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