Plague
Studies from University of Massachusetts, Department of Medicine reveal new findings on plague
Published in Health Risk Factor Week, November 28th, 2006
New research, "Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response," is the subject of a report. According to recent research from the United States, "At mammalian body temperature, the plague bacillus Yersinia pestis synthesizes lipopolysaccharide (LPS)-lipid A with poor Toll-like receptor 4 (TLR4)-stimulating activity. To address the effect of weak TLR4 stimulation on virulence, we modified Y. pestis to produce a potent TLR4-stimulating LPS. Modified Y. pestis was completely avirulent after subcutaneous infection even at high challenge doses."
"Resistance to disease required TLR4, the adaptor protein MyD88 and coreceptor MD-2 and...
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