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Avian Influenza

Researchers identify key genetic changes required for pandemic strains of bird flu

Published in Health Risk Factor Week, December 5th, 2006

By comparing influenza viruses found in birds with those of the avian virus that have also infected human hosts, researchers have identified key genetic changes required for pandemic strains of bird flu.

The new work, reported in the journal Nature, illustrates the genetic changes required for the H5N1 avian influenza virus to adapt to easily recognize the receptors that are the gateway to human cells.

"We identified two changes that are important," said Yoshihiro Kawaoka, the senior author of the Nature paper and a virologist at the University of Wisconsin-Madison School of Veterinary Medicine. "Both changes are needed for the H5N1 virus to...

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