Menopause Risk Factors
Recent findings from Imperial College London, Faculty of Medicine highlight research in menopause risk factors
Published in Health Risk Factor Week, May 8th, 2007
Data detailed in "Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women" have been presented. "Leptin is emerging as a key regulator of bone remodeling. In a population-based study of 1306 postmenopausal Danish women, nonsynonymous LEPR SNPs were associated with risk of adiposity, BMD, and vertebral fracture," researchers in London, the United Kingdom report.
"Smoking exacerbates this LEPR-associated fracture risk. Nonsynonymous single nucleotide polymorphisms (SNPs) in the human LEPR gene have been associated with adiposity in a number of studies, but there have been no large-scale studies...
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