Cholera
Data from M.S.H. Zahid and colleagues advance knowledge in cholera
Published in Health Risk Factor Week, December 23rd, 2008
According to recent research from Dhaka, Bangladesh, "Seasonal epidemics of cholera in Bangladesh are self-limited in nature, presumably due to phage predation of the causative Vibrio cholerae during the late stage of an epidemic, when cholera patients excrete large quantities of phage in their stools. To further understand the mechanisms involved, we studied the effect of phage on the infectivity and survival of V. cholerae shed in stools."
"The 50% infectious dose of stool vibrios in infant mice was similar to 10-fold higher when the stools contained a phage (1.8 x 10(3) to 5.7 x 10(6) PFU/ml) than when stools did not contain a detectable phage. In competition assays...
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