Salk Institute

Salk scientists detect molecular obesity link to insulin resistance, type II diabetes

Published in Health Risk Factor Week, March 17th, 2009

A molecular switch found in the fat tissue of obese mice is a critical factor in the development of insulin resistance, report scientists at the Salk Institute for Biological Studies. Previously found to increase glucose production by the liver during fasting, the culprit—a protein known as CREB—is also activated in fat tissue of obese mice where it promotes insulin resistance.

Their findings, published in the March issue of Cell Metabolism, suggest that CREB activity could provide an early warning for obese people predisposed to develop insulin resistance and may lead to new diabetes treatments that would not require weight loss.

"Obesity is a major...

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Source: Health Risk Factor Week (2009-03-17)

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