Published in Health Risk Factor Week, August 4th, 2009
"The first step in overcoming host restriction is viral entry which is mediated by HA, responsible for both viral attachment and viral/host membrane fusion. HA binds to glycans-containing receptors with terminal sialic acid (SA). It has been shown that avian influenza viruses preferentially bind to alpha 2,3-linked SAs, while human influenza A viruses exhibit a preference for alpha 2,6-linked SAs. Thus it is believed the...
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