Human Papillomavirus
Research on human papillomavirus discussed by scientists at University of North Carolina
Published in Health Risk Factor Week, March 9th, 2010
According to recent research from the United States, "We investigated a gene vaccine strategy against human papillomavirus (HPV)-induced cancer and premalignant diseases, using adeno-associated virus (AAV) vector encoding the viral E7 oncoproteins as the tumor antigens from HPV serotypes 16 (HPV16) and 18 (HPV18). Genetically inactivated E7 proteins were fused with a heat shock protein 70 (hsp70) to minimize the risk of cell transformation and enhance immune responses."
"The fusion protein gene was packaged in AAV serotype 1 or 2 (AAV1 or 2) for efficient in vivo gene expression. that after a single intramuscular injection, the AAV1 vector elicited stronger HPV-specific...
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