Health and Medicine Week
Susan Hasty, Publisher
Table of Contents . . . July 28th, 2003
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Health and Medicine Week | Other Publications
Medical Errors - Planned process failures may help reduce mistakes, expert says
Orthopedics - Study: Stretching exercises can relieve chronic heel pain symptoms
Human Physiology - Study adds to understanding of sense of taste for saltiness
Psychology - Many publications give inaccurate depictions of the state of motherhood
Psychology - Vegetarianism may be associated with eating disorder risk in college women
Tobacco Use - Regulatory strategies to reduce tobacco addiction in youth outlined
AIDS Funding - Kenya NGOs see stiff competition for HIV/AIDS money
Acid Reflux - Condition caused not only by diet but also by genes
Acromioclavicular Surgery - Three techniques can stabilize the acromioclavicular joint
Addiction Medicine - Infant meconium components may expose women who drink during pregnancy
Advocacy - Ohio health advocates form network to protect access to healthcare
Aeromonas Hydrophila - Hemolysin-positive, drug-resistant A. hydrophila is a health threat
Ageing - Gas may form microfoam in blood; antifoaming agents may cure most disease
Aging - Scientists find what type of genes affect longevity
Airway Devices - Core temperature monitoring with new ventilatory devices is accurate
Alcoholism - Alcohol ads stimulate stronger brain responses in drinking than teetotaling teens
Allergy Medicine - Children may outgrow peanut allergies
Alzheimer Disease - Beta amyloid resorption and degradation appears to occur only in astrocytes
Alzheimer Disease - Polymorphisms in the IL-10 promoter region do not appear to be linked
Alzheimer Histology - Formic acid pretreatment may overenhance amyloid plaque, heat does not
Amputation - Amputation surgery in a developing country has poor results
Angiosarcoma - Massive hemothorax occurs as a presenting manifestation of rare tumors
Anisakis Simplex Parasite - High eosinophil cationic protein in serum can aid anisakiasis diagnosis
Anthrax - Germ foils host immune system
Antibody Diversity - Recombination enzyme ERCC1 is not involved in immunoglobulin class switch
Anticoagulant Allergy - Danaparoid is successful in case of heparin induced skin reaction in pregnancy
Antitumor Cytokines - IL-2 and IL-12 appear to induce different mechanisms of macrophage cytoxicity
Antitumor Immunology - TCR Valpha chain interactions provide broad antigen specificity
Arthritis - Aurora Sinai physician performs knee surgery using Stryker technology
Arthritis - Bacteria may play contributing role
Asbestosis Risk - The genotoxic risks from erionite, mordenite may be different due to iron state
Ash Pollen - Skin sensitization is uncommon but can be specific, or to the oleaceae family
Assisted Reproduction - Europe's healthcare systems support trend for quality and quantity in ART
Assisted Reproduction - New method for sorting sperm could improve fertility treatment
Asthma - Atypical cases highlight shortcomings of treatment model
Asthma - Study on baby teeth could give clues to asthma prevention
Asthma Therapy - Combination therapy is efficacious and does not increase airway inflammation
Bacterial Pathogens - Lipotechoic acids activate innate immune system using TLR-2, LBP, CD14
Behavioral Risks - Grants aid development of instrument to screen women for multiple risk factors
Benchmarking - Better-performing groups use benchmarking to improve practices
Benefits - Consumer-directed product suite expanded
Bladder Cancer - Cyclophosphamide is associated with an increased risk of bladder cancer
Bladder Resection - Video cystoscope enables digital pictures and high-frequency cauterization
Breast Cancer - 18-Year follow-up finds no survival difference for mastectomy vs. breast conservation therapy
Breast Cancer - BRCA2 has a role in recombination-mediated double-strand DNA break repair
Breast Cancer - Calcium HA can amplify the pathological process in breast cancer
Breast Cancer - Group warns of crisis in U.K. service provision for patients in coming years
Breast Cancer - Low-dose tamoxifen may be effective treatment, with fewer side effects
Breast Cancer - Mitotic count may be the most important factor for determining prognosis
Breast Cancer - NSAIDs may block development of breast tumors
Breast Cancer - Nipple aspirate fluid a better option for detecting cancer
Breast Cancer - Nutrition and lifestyle factors affect the risk of developing breast cancer
Breast Cancer - Prolactin may be a novel therapeutic target for the treatment of breast cancer
Breast Cancer - Radiotherapy best option after surgery for ductal carcinoma in situ, study says
Breast Cancer - Researchers develop a model of psychosocial support for women with breast cancer
Breast Cancer - Screening mammography reduced excess breast cancer mortality in Sweden
Breast Cancer - There is a relationship between benign breast disease and breast cancer risk
Cancer Diagnosis - Molecular methods of diagnosing cancer offer great advantages
Cancer Screening - Better information needed to help women make an informed choice
Cancer Therapy - Anticancer molecules work together
Cancer Therapy - Virus therapy attacks cancer cells
Cancer in Pregnancy - Treating cancer in pregnancy requires an interdisciplinary approach
Cardiac Arrest - Experts endorse chilling in some patients
Cervical Cancer - Obesity linked to cervical adenocarcinoma, a hormone-dependent cancer
Cervical Cancer - Papillomaviruses can be models to study the mechanism of CpG methylation
Cervical Cancer - Testing method may be culprit behind abnormal Pap test results
Cervical Dystonia - Current botulinum toxin treatment appears to be nonimmunogenic
Chalazion - Chalazion may have a more diffuse clinical presentation
Cholangiocarcinoma - De novo cholangiocarcinoma can occur following liver transplant
Clinical Trials - Survey finds older women most likely would participate again in research
Cochlear Implant - Cochlear implantation can be used in a child with osteogenesis imperfecta
Cochlear Implant - Language development of a handicapped child improves after cochlear implantation
Collaborations - New partner announced in device company joint venture
Collaborations - Rehabilitation program offered in Ashland, Kentucky
Colon Cancer - A subset of premalignant serrated-like polyps may be potentially important
Colon Cancer - Genetic testing for high-risk colon cancer patients has improved risk assessment
Colon Cancer - Prediabetic adults at increased risk
Communications Technology - TriWest Healthcare Alliance contracts with Sprint
Computer-Guided Surgery - Hospital network unveils new procedures for knee, hip replacements
Conjunctival Tumor - Conjunctival nevus of presumed late onset is resected
Contraception - Governor signs bill requiring insurers to cover contraceptives
Contraception - Type of Nortrel contraceptive recalled
Critical Care Medicine - Select Medical opens new hospital in Tennessee
Crohn Disease - Bacterial sensor gets the nod
DNA Testing - Paternity tests help safeguard Guatemalan children slated for foreign adoption
Dementia - Higher education or larger brain size may protect against dementia later in life
Dementia - Lewy bodies are frequently found in familial Alzheimer disease
Depression - Babies exposed to SSRIs in late pregnancy may have neurological symptoms
Dermatology - Imiquimod is a broadly reactive, antiviral, immunostimulatory topical agent
Dermatology - Occupational contact dermatitis is still high, but due to added chemicals
Diabetic Retinopathy - Trial confirms insulin's role in inhibiting leading cause of blindness in adults
Diet - Weight loss, wellness center opens new franchise
Diet and Nutrition - Supplementation for marginal dietary selenium could have functional consequences
Dietary Immune Enhancement - Trace element supplement may improve host defenses even in mild deficiency
Disease Management - New York geriatric HMO adopts chronic care plan
Disease Prevention - Chemotherapy may suppress breast cancer risk in Hodgkin disease survivors
Disease Prevention - Estrogens in HRT may reduce heart disease risk in younger postmenopausal women
Disease Prevention - Prophylactic surgery greatly reduces cancer risk, but by how much is unclear
Down Syndrome - Treadmill training helps kids walk earlier
Drug Allergy - Azathioprine hypersensitivity is rare, may be mistaken for recurrent vasculitis
Electronic Medical Records - Group agrees on healthcare data standards
Electronic Medical Records - HHS launches new efforts to promote paperless healthcare system
Emergency Contraception - Findings indicate women are using EC correctly
End-of-Life Care - Emotional needs of family key to quality ICU care
Endocrinology - Center for Androgen-Related Disorders is first of its kind for women
Endometriosis - Link made to increased risk of some cancers
Enteritis, Sepsis - O-specific polysaccharide structure and antigenicity vary in Citrobacter
Environmental Risk - Leptospira was detected by histology in cattle; antigens found in kidney, liver
Epidemiology - Eating disorders among U.S. Hispanic women are up
Ethics - Patients who request and receive physician-assisted death have high burden of physical pain
Ethics - Scientists debate limits of predictive medicine
Familial Tumors - Peritoneal multifocal calcifying fibrous tumors occur in two sisters
Fernand Widal Syndrome - Aspirin-sensitive rhinosinusitis must be considered a reason for sinus problems
Finance - Blue Cross withdraws conversion plan
Finance - Common stock offering announced by dialysis company
Finance - Excellus BCBS recognized for $8 million in cost-saving pharmacy practices
Finance - Pharmaceutical firm initiates actions to improve profitability
Finance - Second installment of loan received by healthcare information technology company
Fitness - U-M study analyzes best way to increasing strength, mobility of the elderly
Food Contamination - Leptospira is found in fattening pig kidney in Asia; may be a health hazard
Funding - Group wants feds to finance health IT infrastructure
Fungal Infections - Dectin-1 mediates the production of TNF-alpha in the antifungal response
Gastroesophageal Junction - Differentiating metaplasia, Barrett esophagus isn't helped by cytokeratin stain
Gender Studies - Men and women respond similarly to feedback about figure-size
Generics - Generic biopharmaceuticals to hit market over next several years
Genetic Testing - Method of detecting Down syndrome makes life easier for rural Australian women
Genome Organization - Researchers describe translocation in cancer development
HIPAA - Groups seek HHS' help on transactions rules
HIPAA Compliance - Siemens launches new messaging iniatitive to protect privacy
Health Insurance - ODA commends governor for continuing adult dental program
Health Plans - Acquisition of Medicaid line of business complete
Health Policy - Medicaid restrictions on funding for abortions don't alter the sexual landscape
Healthcare Coverage - Excellus BCBS offers preventive care, hospitalization for uninsured, unemployed
Healthcare Economics - Low Medicare reimbursement rate blamed for layoffs
Healthcare Economics - N.C. state health plan, hospital at odds over reimbursements
Hearing Loss - Hearing aid company launches Perseo
Heart Transplant - Perioperative bradycardia has no adverse effects; is associated with amiodarone
Heart Transplantation - Computerized heart monitoring can indicate the need for biopsy
Hemangioma - Cavernous hemangioma seen as enlarging mass on screening mammogram
Hepatic Cancer - An implanted port-catheter system with a fixed tip can be removed
Hepatic Ischemia - The heme oxygenase system is the most critical for protection from injury
Hepatitis C Virus - Alcohol increases virus in human cells
Hepatoblastoma - Hepatoblastoma associated with Beckwith-Wiedemann syndrome, hemihypertrophy
Hepatology - Apoptotic body engulfment by a human stellate cell line is profibrogenic
Hepatology - Microbubble contrast agents improve ultrasound detection of focal liver lesions
Homeostasis - Complement affects cell fate by controlling activation, proliferation, apoptosis
Hospital Closings - Effort made to save Cook County hospital
Human Influenza A - Cynomolgus macaque pathology equivalent to human
Human Spleen - White pulp areas of T, B cells are interdigitating; arterioles cross through
Hypercholesterolemia - Drink more tea to lower cholesterol: VUMC study
Imaging - Wireless technology lets patients relax as color pictures are beamed live from inside their gut
Immune Evolution - Class I molecules of mice, human result of common ancestry, convergent evolution
Implantable Defibrillators - Electromagnetic interferences for implantable defibrillators are numerous
Indigent Care - Mercy Suburban Family Practice offers care regardless of ability to pay
Infection Control - People go to great lengths to avoid restroom germs
Infertility - Emphasis on fertility control in developing countries neglects the infertile
Information Technology - Fischer selects CATSWeb to automate corporate-wide quality tracking system
Information Technology - M.D. On-Line selects NPC to support electronic payment processing
Information Technology - Vitria acquires rights to healthcare contract management software
Insect Sting Allergy - Levels of IgE antibodies are not predictive for fatal anaphylaxis to hymenoptera
Insurance Trends - New HMO report examines uninsured rates
Kidney Transplant Risk - Polyomavirus infection can appear to be acute vascular rejection
Legal Issues - Cigna, doctors hope to revise settlement by September 2003
Legal Issues - HCA receives approval of settlement agreement with Justice Dept., pays CMS settlement
Legal Issues - More physicians linked to limits on non-economic damages
Legal Issues - Obesity lawsuits are no diet aide, study reveals
Legal Issues - Suit to be filed on behalf of victims of Accutane side effects
Legal Issues - Tenet urged to release Mercer Report on Redding Medical Center
Legionnaires Disease - Officials baffled by reported increase in cases
Legislative Issues - Democrats kill medical malpractice bill
Leukemia - Childhood leukemia increased in Northwest Italy, 1975-1998
Leukemia - Researchers identify factors affecting bone marrow transplant outcome
Leukemia - Unrelated donor bone marrow transplantation for acute mixed lineage leukemia
Leukemia Inhibitory Factor - The immunoglobulin-like domain of the LIF receptor modulates LIF affinity
Liver Transplantation - It is possible to acquire hemophilia A from a hemophiliac donor liver
Lung Cancer - p53 mutation was not related to patient survival in some lung cancer patients
Lung Transplant - Statin therapy gives less inflammation, better lung function, high survival
Lymphangioma - Morbidity increases if the lymphangioma exceeds the midline of the body
MHC Mapping - All available short tandem repeats in the human MHC have been mapped
MHC-I Binding Sites - Heat shock protein 60 binds the MHC-Ia's Qa-1, but not on peptide Qdm
MHC-I Gene Family - Only nine MICB alleles were found to be present in the Spanish population
Market Analysis - Decision Resources enters partnership with drug discovery publication
Market Analysis - Groups to study global trends in hospital governance
Market Analysis - Pharma leaders cut years off drug development time
Market Analysis - Pharmacist shortage continues unabated
Mathematical Modeling - Clonal exhaustion results from interclonal regulation
Medicaid - Report says proposals pose threat to mental health safety net
Medicaid - U.S. oversight of quality of care criticized
Medical Education - AAMC issues new report on bioterrorism education for medical students
Medical Education - Wayne State hires CampusMobility to created med school mobile initiative
Medicare - Bonus payments doing little to resolve doctor shortage
Medicare - Cap on drug benefits could mean big increase in out-of-pocket expenses
Medicare - Doctors making house calls in poor areas
Medicare - Group wants ensured continued reimbursement once HIPAA is effective
Medicare - Medical expenses similar for white, black, Hispanic seniors
Medicare - New Orleans charity hospital improperly billed program for over $1.8 million
Medicare - Rhode Island insurer wants to stop handling claims
Melanoma - Gene-expression profiling in human cutaneous melanoma profiles genetic changes
Melanoma - Melanoma incidence rates are not stabilizing in the U.S.
Melanoma - Vertical growth in certain melanomas is a significant prognostic factor
Menopause - Clinical trial tests whether black cohosh and red clover relieve symptoms
Menopause - Flaw revealed in so-called "grandmother hypothesis"
Menstruation - Study shows ovulation frequently occurs more than once a month
Mergers and Acquisitions - Company completes acquisition of Medicaid line of business from Florida firm
Mergers and Acquisitions - HealthSmart acquires North Texas Healthcare Network
Mergers and Acquisitions - Information technology company buys healthcare billing firm
Mergers and Acquisitions - Kessler Rehabilitation Corp. to be acquired by Select Medical
Mergers and Acquisitions - Nutraceutical firm completes acquisition of health foods chain
Mergers and Acquisitions - SunLink to extend HealthMont merger agreement
Mergers and Acquisitions - Tender offer for all outstanding shares of pharmaceutical firm expires
Metastasis - Testicular metastasis can occur from squamous cell carcinoma of the lung
Microbial Pathogens - Mannose-binding lectin activation may not be linked to susceptibility decrease
Migraine - Headaches devastating to children's quality of life
Migraine Headache - Increased blood flow to rostral brainstem, neuronal hyperexitability involved
Migraine Trends - Drug market to double from $2.86 billion in 2002 to $5.6 billion in 2012
Miscarriage - Recurrent pregnancy loss may be associated with defective sperm
Multiple Myeloma - Macrophage inflammatory protein 1-alpha may be a major contributor to disease
Multiple Sclerosis - New blood test may help with diagnosis
Multiple Sclerosis - Patients have higher amylolytic activity in their IgM and IgG antibodies
Multiple Sclerosis - Study documents risk of developing MS 10 years after having optic neuritis
Mycobacterium Leprae - PCR provides efficient detection of multidrug resistance in leprosy
Nerve Sheath Tumors - Schwann cell is the source of heterologous elements in nerve sheath tumors
Neurilemmoma - Neurilemmoma attached to the tendon of the flexor digitorum longus muscle
Nicotine Addiction - Smokers who first lit up as teens more likely to smoke after stroke
Nicotine Addiction - Study examines factors related to adolescents' viewing of smoking in movies
Novel Antimicrobials - Hepcidin-like antimicrobial peptides appear to be common in bony fish
Nutrition - Gender preferences in 'comfort' foods stem from childhood
Nutrition - HHS to require food labels to include trans fat contents
Nutrition - Omega-3 fatty acids formulated as stable, dry powder
Nutrition - Organization emphasizes benefits of vitamins
Nutritional Therapy - Chronic fatigue syndrome may be helped by lactic acid bacteria therapy
Obesity - Ancestry mix may be one piece of puzzle
Obesity - Wisconsin gets $2 million to trim obesity rate
Ophthalmology - AcrySof natural single-piece IOL earns FDA approval
Ophthalmology - Disarming 'glial' cells may solve retinal transplantation barrier
Orolaryngeal Cancer - EH polymorphisms are important in the risk of orolaryngeal cancer in Caucasians
Osteoma - Frontoethmoidal osteoma removed via stereotactic-assisted sino-orbital approach
Otoplasty - Molding the ears after anterior scoring and concha repositioning is successful
Ovarian Cancer - Age affects survival rates in women with advanced disease
Pain Control - Association produces brochure to help patients manage pain
Palliative Care - Family caregivers providing terminal, palliative care at home need more support
Pancreatic Pain - Pain produced by chronic pancreatitis could be through neuroimmune interaction
Paraneoplastic Pemphigus - Rare paraneoplastic pemphigus with bronchiolitis obliterans occurs in a child
Parkinson Disease - Nicotinamide N-methyltransferase is high in cerebellum; may be pathogenic
Patient/Physician Relationship - Many doctors don't tell patients about services not covered by insurance
Pediatric Cancer - Leukemia is the most common underlying cancer in children with seizures
Pediatric Cancer - Preservation of fertility in children must be considered before cancer treatment
Pediatric Obesity - Many eating patterns linked to obesity in Louisiana kids
Pediatric Proteinuria - Prednisolone/cyclophosphamide eliminates Heinloch-Schonlein purpura nephritis
Pediatric Tumors - Bilateral sternocleidomastoid tumor of infancy is rare
Personnel - Broderick joins dialysis company
Personnel - Executives attracted to Pittsburgh for biotech greenhouse
Personnel - Expanded management team to direct growth of information technology firm
Personnel - Gentiva names Cathy S. Newhouse as VP, special programs
Personnel - Monnig added to board of directors of liability insurer
Personnel - New leadership appointed at care management company
Personnel - Zan F. Calhoun appointed president, OAO Healthcare Solutions, Inc.
Pharmaceutical Trends - Study offers three cases modeling prescription brand impact
Physician Orders - Computerized physician order entry reported succeeding in community hospitals
Pituitary Cancer - Leptin may be associated with invasiveness in functional pituitary adenomas
Platelet Activation - LIM and LASP are substrates for cGK in human platelets
Platelet Reactive Antibodies - Progress is being made toward diagnostics for platelet alloimmune syndromes
Podiatry - New guidelines released on toe-joint disorders
Prematurity - Tracking premature babies: Girls grow bigger than boys
Prenatal Health - Low cholesterol may damage fetal development
Preparedness - Perceptions about the threat of bioterrorism could impair the U.S. response
Preventive Medicine - Pennsylvania health department receives grant for diabetes control
Primate Evolution - Human and rhesus macaque CD1e molecules localization and function are conserved
Privacy Issues - Certification Program for Business Associates announced
Progenitor Cells - Notch proteins can induce T cells in a culture used for B cell development
Prostate Cancer - Gamma scintillation meter can detect pulmonary seed embolization
Prostate Cancer - It is difficult to get South African men with elevated PSA to undergo biopsy
Prostate Cancer - MR slice-to-volume registration can accurately aid image-guided therapy
Prostate Cancer - Overcoming multidrug resistance in prostate cancer may be feasible
Prostate Cancer - Physicians offer custom-made treatment
Pulmonary Medicine - Female smokers experience more respiratory symptoms than male smokers
Quality Assurance - HEDIS 2004 contains 10 new measures addressing public health, service issues
Quality Assurance - Landmark study finds American adults often fail to get recommended care
Quality Assurance - Study: New York HMOs still above national average, but slow to improve
Quality Improvement - Insurance provider offers performance-based reward system
Radiation Exposure - Prelminary evidence of radiation exposures in Kazakhstan is inconclusive
Radius Tumors - Reconstruction of the radius with a radiofibular plate and K-wire is successful
Rectal Leiomyoma - Rectum leiomyoma occurs in a 10-month-old female
Regulatory Issues - Global receivership database for monitoring company insolvency considered
Respiratory Failure - Survival of patients depends on health of other organs
Restructuring - Large Michigan Medicaid HMO forced to reorganize
Rheumatology - Adult onset Still disease may risk hepatic failure with increased IL-18 and HGF
Risk Factors - Anger, anxiety may boost heart risk in postmenopausal women
SARS - Higher public health awareness could be 'silver lining' of outbreaks
SARS - Liu: How Singapore scientists tackled outbreak
SARS - Outbreak contained worldwide but threat remains and more research needed
Schistosoma Mansoni - RNA interference method allows suppression of cathepsin B expression
Sexually Transmitted Diseases - Infections continue to rise in the U.K.
Skin Antibacterial - Beta-defensin 2 is in intercellular spaces and in keratinocyte lamellar bodies
Sperm Preservation - Air-dried sperm could allow home storage
Sports Medicine - Early heart disease in non-menstruating female athletes is reversible
Squamous Cell Carcinoma - Certain features of squamous cell carcinoma are common in transplant recipients
Staffing - Hospitals recruit more men for nursing
Streptococcus Agalactiae - Neonates and mothers have the same strain, but no strain appears more virulent
Stress - Chill out: Anger can give you a headache
Stress - Magnesium supplementation may help reduce stress
Stroke - Primary care doctors make a difference in deaths
Stroke - Stem-like cells from peripheral blood restore function in rats
Surrogacy - Study finds surrogate mothers have no doubts about handing over the baby
TMJ Disease - IL-6 in synovium may be related to the grade of joint effusion in jaw
Talar Chondroblastoma - Chondroblastoma of the talus can be treated with osteochondral autograft
Telemedicine - Study finds virtual consultations are not cost effective
Tendon Function - ATP modulates load-inducible IL-1 beta, COX 2, and MMP-3 expression in tendons
Tendon Structure - Collagen fibrils in tendons are inhomogeneously structured
Testicular Tumor - Diffuse fibrous pseudotumor of the testicular tunics can occur with a hydrocele
Thyroid Cancer - Pretreatment with rhTSH reduces retention of 131I
Tissue Culture - Smooth muscle has a more normal phenotype when grown on homologous substrate
Tracheal Reconstruction - Researchers engineer trachea using sheep nasal chondrocytes and epithelial cells
Transplant Medicine - Hepatologists recommend pretransplant biopsy for living donor liver transplants
Transplant Medicine - Laryngotracheal transplantation improves patient quality of life
Transplant Medicine - Reasonable prospect of benefit must be weighed against risk
Transplant Policy - OPTN/UNOS board acts to assess, facilitate living organ donation
Transplant Risk - Haemophilus parainfluenza and IgA deposition may cause nephrotic syndrome
Urinary Tract Infection - Antibiotic resistance may be due to E. coli biofilm inside bladder cells
Vibrio Vulnificus - Seawater exposed wounds, eating raw seafood are risks magnified by bad health
Vitamin Deficiency - Cigarette smoke linked to low folate levels
Vulva Tumors - Metastatic tumors of the vulva are rare
West Nile Virus - Spectrum of symptoms includes paralysis
Wilms Tumor - Serial abdominal ultrasounds in Klippel-Trenaunay patients are unwarranted
Women's Health - Novispirin G-10 is active against Chlamydia trachomatis and vaginosis agents
Wound Healing - Fibroblast growth factor receptors FGFR1, 2 are in healing mouth myofibroblasts
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